Professor Costanzo earned degrees in medicine and surgery from the University of Naples Federico II in 1998, followed by a Ph.D. in cellular and molecular biology and pathology from the same institution, in 2002. He completed his training at Columbia University in 2004 in the laboratory of Jean Gautier, Department of Genetics and Development.
He subsequently joined the London Research Institute’s Clare Hall Laboratories, where he founded the Genome Stability Laboratory, working closely with 2001 Nobel laureate Tim Hunt, with whom he co-authored several important studies on the control of DNA replication.
More recently, Costanzo has collaborated with the research team of 2012 Nobel laureate John Gurdon, whose discoveries on cellular reprogramming in Xenopus have led to the identification of molecules involved in the formation of embryonic stem cells.
In 2013, Costanzo started the DNA metabolismresearch program at Institute of Molecular Oncology in Milan, Italy.