CANCER
- INTERNATIONAL JOURNAL OF CANCER/2024
Ligorio, Francesca et al. “Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial.” International journal of cancer vol. 154,1 (2024): 114-123. doi:10.1002/ijc.34701
- CANCER RESEARCH/2024
Raucci, Franca et al. “Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia.” Cancer research vol. 84,7 (2024): 1133-1148. doi:10.1158/0008-5472.CAN-23-0295
- CANCERS/2024
Buono, Roberta et al. “Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival.” Cancers vol. 15,24 5870. 16 Dec. 2023, doi:10.3390/cancers15245870
- EUROPEAN JOURNAL OF CANCER/2022
Ligorio, Francesca et al. “Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub-analysis of the NCT03340935 trial.” European journal of cancer (Oxford, England : 1990) vol. 172 (2022): 300-310. doi:10.1016/j.ejca.2022.05.046
- CELL REPORTS/2022
Cortellino, Salvatore et al. “Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects.” Cell reports vol. 40,8 (2022): 111256. doi:10.1016/j.celrep.2022.111256
- AGING CELL/2022
Rahmani, Jamal et al. “Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.” Aging cell vol. 21,2 (2022): e13540. doi:10.1111/acel.13540
- CANCER DISCOVERY/2022
Vernieri, Claudio et al. “Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.” Cancer discovery vol. 12,1 (2022): 90-107. doi:10.1158/2159-8290.CD-21-0030
- CANCERS/2021
Valdemarin, Francesca et al. “Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment.” Cancers vol. 13,16 4013. 9 Aug. 2021, doi:10.3390/cancers13164013
- NATURE/2020
Caffa, Irene et al. “Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.” Nature vol. 588,7839 (2020): E33. doi:10.1038/s41586-020-2957-6
- BREAST CANCER RESEARCH AND TREATMENT/2021
Lugtenberg, Rieneke T et al. “Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial.” Breast cancer research and treatment vol. 185,3 (2021): 741-758. doi:10.1007/s10549-020-05991-x
- NATURE COMMUNICATIONS/2020
de Groot, Stefanie et al. “Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.” Nature communications vol. 11,1 3083. 23 Jun. 2020, doi:10.1038/s41467-020-16138-3
- NATURE COMMUNICATIONS/2020
Di Tano, Maira et al. “Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.” Nature communications vol. 11,1 2332. 11 May. 2020, doi:10.1038/s41467-020-16243-3
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Diet analysis suggests lipid imbalance slows cancer Giulia Salvadori & Valter D. Longo PDF
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Starvation, Stress Resistance, and Cancer – Cell Press 2018 PDF
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Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer
and Chemotoxic Resistance in Aged Mice – Scientific Reports 2017 PDF -
Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy – Plos 2017 PDF
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Protective effects of short-term dietary restriction in surgical stress and chemotherapy – Elsevier 2017 PDF
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Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions – American Association for Cancer Research 2016 PDF
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Safety and feasibility of fasting in combination with platinum-based chemotherapy – BioMed Central 2016 PDF
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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity – Cancer Cell 2016 PDF
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Fasting and Caloric Restriction in Cancer Prevention and Treatment – 2016 PDF
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Growth factors, aging and age-related diseases – Elsevier 2016 PDF
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Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition – Oncotarget 2015 PDF
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Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models – Oncotarget 2015 PDF
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Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression – Elsevier 2013 PDF
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A small group of Ecuadorians with a rare genetic disorder could hold a key to cancer and other age-related illness – Discover 2013 PDF
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Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer – 2013 PDF
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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy – Science Translational Medicines 2012 PDF
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Starvation, detoxification, and multi-drug resistance in cancer therapy – Elsevier 2012 PDF
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Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy – Plos 2012 PDF
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Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients – NPG 2011 PDF
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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model – Jove 2011 PDF
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Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index – Cancer Research 2010 PDF
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Fasting and cancer treatment in humans: A case series report – Impact Aging 2009 PDF
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Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy – PNAS PDF
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Turning anti-ageing genes against cancer – Nature Reviews 2008 PDF
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Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system – The Journal of Cell Biology 2008 PDF
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A simple model system for age-dependent DNA damage and cancer – Elsevier 2007 PDF
READ MORE ABOUT CANCER
NEURODEGENERATIVE DISEASES
- CELL REPORTS/2022
Rangan, Priya et al. “Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models.” Cell reports vol. 40,13 (2022): 111417. doi:10.1016/j.celrep.2022.111417
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Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans – The Journal of Neuroscience 2017 PDF
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A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms – Cell Reports 2016 PDF
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Supplementary – Cell Reports 2016 PDF
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Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer’s disease mouse model – Aging Cell 2013 PDF
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Supporting info – Aging Cell 2013 PDF
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Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain – The Scientific Cell 2010 PDF
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Progesterone Influence on Neurite Outgrowth Involves Microglia – Endocrinology 2009 PDF
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SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons – Cell Press 2008 PDF
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Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging – Neuroscience Letters 2004 PDF
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Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP – Neurobiology Aging 2004 PDF
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Peroxynitrite Mediates Neurotoxicity of Amyloid -Peptide1–42- and Lipopolysaccharide-Activated Microglia – The Journal of Neuroscience 2002 PDF
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Estradiol (E2) Enhances Neurite Outgrowth by Repressing Glial Fibrillary Acidic Protein Expression and Reorganizing Laminin – Endocrinology PDF
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Genetics of Aging and Diseases – ArchNeuro 2002 PDF
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Reversible Inactivation of Superoxide-Sensitive Aconitase in Ab1–42-Treated Neuronal Cell Lines – Journal of Neurochemistry 2000 PDF
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Variations of Synaptotagmin I, Synaptotagmin IV, and Synaptophysin mRNA Levels in Rat Hippocampus during the Estrous Cycle – Experimental Neurology 1999 PDF
READ MORE ABOUT NEURODEGENERATIVE DISEASES
AUTOIMMUNE DISEASES
- THE JOURNAL OF NUTRITION/2024
Hadžić, Kajs et al. “Restrictive diets have a beneficial impact on dextran sodium sulfate-induced colitis in male mice.” The Journal of nutrition vol. 154,1 (2024): 121-132. doi:10.1016/j.tjnut.2023.11.005
- CELL REPORTS/2019
Rangan, Priya et al. “Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology.” Cell reports vol. 26,10 (2019): 2704-2719.e6. doi:10.1016/j.celrep.2019.02.019
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Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence – HHS Public Access PDF
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Enhancing Stem Cell Transplantation with ‘‘Nutri-technology’’ – Cell Press 2016 PDF
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A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms – Cell Reports 2016 PDF
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Supplementary – Cell Reports 2016 PDF
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Fasting transformed me after medicine failed; This free, simple therapy has changed my life. Could it be the panacea to transform the NHS? – The Times (London) 2015 PDF
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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based
Regeneration and Reverse Immunosuppression – Cell Press 2016 PDF
READ MORE ABOUT AUTOIMMUNE DISEASES
CARDIOVASCULAR DISEASES
- EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY/2022
Nardon, Mauro et al. “Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial.” European journal of applied physiology vol. 122,3 (2022): 651-661. doi:10.1007/s00421-021-04867-2
- JOURNAL OF CLINICAL PSYCHOLOGY/2020
Maniaci, Giuseppe et al. “Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial.” Journal of clinical psychology vol. 76,10 (2020): 1807-1817. doi:10.1002/jclp.22971
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Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure – Journal of the American Collage of Cardiology 2017 PDF
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Dietary Interventions, Cardiovascular Aging, and Disease – 2016 PDF
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Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality – American Medical Association 2016 PDF
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Growth Factors, Nutrient Signaling, and Cardiovascular Aging – Circulation Research 2012 PDF
READ MORE ABOUT CARDIOVASCULAR DISEASES
DIABETES & OBESITY
- DIABETOLOGIA/2024
van den Burg, Elske L et al. “Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial.” Diabetologia, 10.1007/s00125-024-06137-0. 28 Mar. 2024, doi:10.1007/s00125-024-06137-0
- NATURE COMMUNICATIONS/2024
Brandhorst, Sebastian et al. “Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk.” Nature communications vol. 15,1 1309. 20 Feb. 2024, doi:10.1038/s41467-024-45260-9
- THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM/2022
Sulaj, Alba et al. “Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study.” The Journal of clinical endocrinology and metabolism vol. 107,8 (2022): 2167-2181. doi:10.1210/clinem/dgac197
- BMC ENDOCRINE DISORDERS/2020
van den Burg, Elske L et al. “Correction to: Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes.” BMC endocrine disorders vol. 20,1 164. 4 Nov. 2020, doi:10.1186/s12902-020-00635-z
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Fasting-Mimicking Diet Promotes Ngn3-Driven b-Cell Regeneration to Reverse Diabetes – Cell Press 2017 PDF
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Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans – Science Translational Medicine 2011 PDF
READ MORE ABOUT DIABETES & OBESITY
LONGEVITY & AGING
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Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production – Cell Press 2017 PDF
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Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease – Science Translational Medicine 2017 PDF
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Impact of intermittent fasting on health and disease processes – Elsevier 2016 PDF
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Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan – Cell Press 2016 PDF
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A Protein Restriction-Dependent Sulfur Code for Longevity – Cell 2015 PDF
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A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan – Cell Press 2015 PDF
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Protein and amino acid restriction, aging and disease: from yeast to humans – CellPress 2014 PDF
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Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging – Plos Genetics 2014 PDF
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Treat ageing – Comment 2014 PDF
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Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population – Cell Press 2014 PDF
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Fasting: Molecular Mechanisms and Clinical Applications – Cell Press 2014 PDF
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Longo, V.D. and S. Panda, Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab, 2016. 23(6): p. 1048-59. PDF
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Longo, V.D. and S. Cortellino, Enhancing Stem Cell Transplantation with “Nutri-technology”. Cell Stem Cell, 2016. 19(6): p. 681-682. PDF
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Acetyl-CoA Synthetase Is a Conserved Regulator of Autophagy and Life Span – Cell Press 2014 PDF
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SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice – Aging Cell 2014 PDF
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Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity – Aging Cell 2014 PDF
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Somototropic Signaling: Trade-offs between growth, reproductive development, and longevity – American Physiological Society 2013 PDF
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This baby will live to be 120 – National Geographic 2013 PDF
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Assessing Chronological Aging in Saccharomyces cerevisiae – 2013 PDF
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Assessing Chronological Aging in Bacteria – National Institutes of Health 2013 PDF
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A Radical Signal Activates the Epigenetic Regulation of Longevity – Cell Press 2013 PDF
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Chronological Aging in Saccharomyces cerevisiae – 2012 PDF
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GRP78/BiP is a Novel Downstream Target of IGF-1 Receptor Mediated Signaling – American Physiological Society 2012 PDF
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Replicative and Chronological Aging in Saccharomyces cerevisiae – Cell Press 2012 PDF
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Intermittent supplementation with rapamycin as a dietary restriction mimetic – Aging 2011 PDF
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Lifespan extension and paraquat resistance in a ubiquinone‐deficient
Escherichia coli mutant depend on transcription factors ArcA and TdcA – Impact Aging 2011 PDF -
Extending Healthy Life Span—From Yeast to Humans – Science Mag 2010 PDF
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Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation – Plos Genetics 2010 PDF
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Comparative analyses of time-course gene expression profiles of the long-lived sch9D mutant – Oxford Univ. Press 2010 PDF
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E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase – 2010 PDF
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Aging and Dietary Restriction: The Yeast Paradigm – 2010 PDF
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E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase – 2010 PDF
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Genome-wide screen identifies Escherichia coli TCA cyclerelated mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA – National Institutes of Health 2010 PDF
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Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension – Plos Genetics 2009 PDF
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Linking sirtuins, IGF-I signaling, and starvation – Elsevier 2009 PDF
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Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors
Downstream of Ras/PKA, Tor, and Sch9 – Plos Genetics 2008 PDF -
The Budding Yeast Saccharomyces cerevisiae: Oxidative Stress and Aging in Saccharomyces cerevisiae – 2008 PDF
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The chronological life span of Saccharomyces cerevisiae to study mitochondrial
dysfunction and disease – Elsevier 2008 PDF -
Programmed Longevity and Programmed Aging Theories – 2008 PDF
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Chronological aging-induced apoptosis in yeast – Elsevier 2008 PDF
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Aging and Dietary Restriction: The Yeast Paradigm – 2010 PDF
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Chronological aging-induced apoptosis in yeast – Elsevier 2008 PDF
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Significant and Systematic Expression Differentiation in Long-Lived Yeast Strains – Plos One 2007 PDF
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The Chronological Life Span of Saccharomyces cerevisiae – Methods in Molecular Biology 2007 PDF
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Inference of transcription modification in long-lived yeast strains from their
expression profiles – BMC Genomics 2007 PDF -
The Chronological Life Span of Saccharomyces cerevisiae – Methods in Molecular Biology 2006 PDF
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Macrosialin increases during normal brain aging are attenuated by caloric restriction – Elsevier 2005 PDF
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Programmed and altruistic ageing – Perspectives 2005 PDF
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Can Aging Be Switched Off? – Moscow State University 2005 PDF
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Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae – The Journal of Cell Biology 2004 PDF
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Superoxide Inhibits 4Fe-4S Cluster Enzymes Involved in Amino Acid Biosynthesis – Journal of Biological Chemistry 2004 PDF
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Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians? – Aging 2003 PDF
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Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic – Elsevier 2003 PDF
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The Ras and Sch9 pathways regulate stress resistance and longevity – Elsevier 2003 PDF
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The chronological life span of Saccharomyces cerevisiae – Aging Cell 2003 PDF
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Regulation of Longevity and Stress Resistance by Sch9 in Yeast – Science Magazine 2001 PDF
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Mutations in signal transduction proteins increase stress resistance and
longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells – Elsevier 1999 PDF -
Mitochondrial Superoxide Decreases Yeast Survival in Stationary Phase – Ideal 1999 PDF
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Biodemographic Trajectories of Longevity – Science Magazine 1998 PDF
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Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and
Delays Death of Wild-Type Yeast – The Journal of Cell Biology 1997 PDF -
Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae – The Journal of Biological Chemistry 1996 PDF